Colony Preparations
by Evan Lorentz

Thanks to the download of a Colony, this may be the only mission you need to complete to win the game -- and it's universal. What more could you ask for? Mission Specialist bonuses? Try forming a Treaty with the Federation, who can provide both Geology and Biology specialists. Getting to the Gamma Quadrant adds a minor complication, but it can be dealt with. You can use Wormholes (including the Bajoran variety) to get there, or use mechanisms allowing you to report straight to the Gamma Quadrant.

Combos:
I.K.C. T'Ong + Space/Time Portal + Colony Preparations: Report your Klingons aboard the T'Ong straight to the Gamma Quadrant, beam them down to the planet, then pull the empty ship back to your hand and do it again.

The Emissary + Colony Preparations: Simply add new Bajoran colonists to the completed mission without traveling back to the Alpha Quadrant to pick them up.